Midodrine

Other

IV DoseNo IV form
Oral doseAdults: 10 mg TID recommended, 3rd dose not later than 6 pm.
Levelsunknown
KineticsDirect effect of metabolite on alpha receptors. Peak levels of metabolite at 1-2 hours, half-life of 3-4 hours.
CautionsSupine and/or sitting hypertension should be checked for after initiation of therapy. Symptoms may include heart pounding, headache, blurred vision.
InteractionsMay potentiate vagal bradycardia with digoxin. Avoid other vasoconstrictors (e.g. phenylephrine, phenylpropanolamine, dihydroergotamine) Effects antagonized by prazosin)
PreparationsProAmatine scored tablets, 2.5, 5 mg
FDA approval in childrenno