|IV Dose||Loading does: 1 mg/kg, given no faster than 50 mg/min.|
May repeat twice q 5-10 mins.
Drip 20-50 ug/kg/min.
Decrease rate by 50% at 24 hours!
|Oral dose||No PO form (although mexiletine is similar)|
Toxicity (esp. confusion) frequent >6 ug/ml.
|Kinetics||Elimination half-life 1.8 hours in adults and children aged 6 m- 3 years, 3.2 hours in neonates.|
Decreased clearance in congestive heart failure.
|Cautions||Vertigo, paraesthesias, slurred speech and confusion are the first signs of toxicity.|
|Interactions||Propranolol decreases liver blood flow and lidocaine clearance.|
Isoproterenol, phenobarbital, phenytoin increase clearance.
|Preparations||Xylocaine injection, 100 mg/5 cc (amps or syringes)|
|FDA approval in children||yes|