Ibutalide
Class III
IV Dose | 0.01 mg/kg over 10 minutes (under 60 kg) 1-2 mg over 10 minutes (over 60 kg) |
Oral dose | |
Levels | |
Kinetics | Highly variable. Half-life averages 6 hours (2-12 hours) |
Cautions | VT or torsades de pointes in 9% as late as 4 hours after the dose. Do not give if there is hypokalemia or preexisting QT prolongation. Requires electrocardiographic monitoring in a critical care setting >4 hours. |
Interactions | Do not give with Class I or III antiarrhythmics |
Preparations | Corvert injection, 0.1 mg/cc., 10 cc vial = 1 mg |
FDA approval in children | no |