Esmolol
Class II
| IV Dose | 500 ug/kg/min for 1 minute, then 50 ug/kg/min. Repeat bolus in 5 minutes, increase infusion to 100 ug/kg/min if no effect. Further increases with boluses up to 200 ug/kg/min as necessary |
| Oral dose | |
| Levels | unknown |
| Kinetics | Elimination half-life 9 minutes. |
| Cautions | Hypotension occurs transiently in 44%. CNS side effects are common, esp. emesis (16%). |
| Interactions | Increases digoxin levels by 10-19%. Levels increased by warfarin, morphine. |
| Preparations | Breviblock injection, 2.5 grams/10 ml ampule |
| FDA approval in children | no |