Mexiletine
Class Ib
| IV Dose | No IV form |
| Oral dose | Children: 1.4-5.1 mg/kg/dose, given q 8 hours. May increase to 8.0 mg/kg/dose in infants. Adults: 450-1200 mg/day divided TID |
| Levels | 0.8-2.0 ug/ml Poor correlation with therapeutic efficacy |
| Kinetics | Elimination half-life 6.3-11.8 hours in adults Increased to 15.4 hours in heart failure. Peak levels 1-3 hours after oral dose |
| Cautions | |
| Interactions | Phenytoin, rifampin increase clearance |
| Preparations | Mexitil capsules: 150, 200, 250 mg |
| FDA approval in children | no |