Class II

IV Dose0.02 mg/kg every 5 min to 0.1 mg/kg total dose.
Oral dose2 mg/kg/day divided q 6 hours to start. Increase routinely to 5 mg/kg/day. May in rare circumstances go to 14 mg/kg/day, watching levels. Inderal LA should be given BID in children
Levels25-150 nanograms/ml for beta blockade. 150-1000 ng/ml for control of VT.
KineticsLarge first-pass metabolism in liver. Elimination half-life 4-6 hours. (T 1/2 of 4-hydroxy-P 5.2-7.5 hours, active). Peak levels at 2-3 hours after oral dose.
CautionsContraindicated in asthma, congestive heart failure. Beware hypoglycemia in infants and diabetics
InteractionsLevels increased by cimetidine. Contraindicated with verapamil, due to synergistic negative inotropic effect and cardiovascular collapse Increases hepatic lidocaine metabolism.
PreparationsInderal scored tabs: 10, 20, 40, 60, 80, 90 mg. Inderal LA capsules: 60, 80, 120, 160 mg. Inderal injection, 1 mg/1 ml ampules
FDA approval in childrenyes